MReS+PhD in Sensor Technologies (Fixed Term)

This is a four-year studentship funded by Astra Zeneca and will be in collaboration with the Cambridge EPSCR Centre for Doctorial Training in Sensor Technologies for a Sustainable Future. It is an interdisciplinary and research focused training programme which introduces our students to the breadth of sensor technologies and applications while providing depth in key topics. The programme ranges from the physical concepts of sensing via the interpretation and management of sensory data to modern developments in sensor applications.

The programme is structured as a one year Master of Research (MRes) course followed by a three year PhD research project. Throughout the course students are part of a student cohort which offers extensive peer-to-peer learning opportunities and exposure to cutting-edge R&D in academia and industry. In addition to developing their technical and scientific knowledge our students receive continuous training in research, team and leadership skills. Entry is competitive and we are looking for students who are curious and passionate team players who are keen to work towards a more healthy and sustainable future.

Title of the PhD project is "Multispecific antibodies stoichiometry at the single-molecule level".

Multispecific antibodies (MAbs) are a new biologics class offering novel and differentiated therapeutic possibilities. These are currently finding applications in oncology, respiratory medicine, and immunology. However during manufacture of these important materials, a variety of unwanted states are formed. Conventional 'ensemble'-based biophysical methods such as mass spectrometry, chromatography, electrophoresis, or spectroscopy methods, lack the sensitivity to characterise this structural diversity at the level and single antibodies, therefore a new more sensitive method is required.

This multidisciplinary PhD will involve developing single-molecule fluorescent microscopy methods to help quantify diversity within Multispecific antibodies, it would suit someone with a background in physical chemistry, biophysics, photonics and electrical engineering. It will involve a combination of biochemistry, physical chemistry, image analysis and optical microscopy. You will need to have obtained a first, or upper second class, honours degree (or equivalent) in a relevant undergraduate course.

More information is available here: https://cdt.sensors.cam.ac.uk

Funding: The funds for this post are available for 4 years. *Due to funding restrictions the studentship is only available at the "Home rate" (https://www.postgraduate.study.cam.ac.uk/finance/fees). Overseas applicants can apply but will be required to cover the difference between the "Home" and "Overseas" fee rate.

All applications should be made online via the University's Applicant Portal, here: https://www.postgraduate.study.cam.ac.uk/courses/directory/egcepdsta, where you can also find full eligibility and course details.

We particularly welcome applications from women and /or candidates from a BME background for this post as they are currently under-represented at this level in our department.

Closing date for applications is 12th February 2023.

Interviews will be held soon after the closing date.

If you have any queries regarding the studentship, please contact Adriana Wolf, Sensor Administrator, at admin@sensors.cam.ac.uk.

Please quote reference NQ35163 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.